1 Extended half-life (EHL) recombinant FIX (rFIX) products aim to reduce the treatment burden for prophylaxis by allowing reduced dosing frequency while maintaining higher trough levels of FIX activity than are achieved with SHL FIX products. However, frequent infusions may negatively impact patient quality of life and adherence to treatment. 1 Traditional standard half-life (SHL) FIX concentrates require frequent infusions to achieve adequate prophylaxis and prevent bleeds. Prophylaxis with coagulation factor IX (FIX) is recommended for patients with severe hemophilia B and for those with nonsevere hemophilia B with a severe bleeding phenotype.
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